Event Date
Speaker: Huabo Su, Ph.D., Professor, Vascular Biology Center, Medical College of Georgia, Augusta University
Title: Neddylation, an emerging mechanism governing cardiovascular health
Host: Manuel Navedo, Ph.D., Professor, Department of Pharmacology
Neddylation is a ubiquitin-like post-translational modification that regulates the stability, activity, subcellular localization, and interaction of diverse protein substrates. Although accumulating evidence implicates neddylation in multiple human diseases, its roles in cardiovascular development, homeostasis, and pathology remain incompletely understood. Using genetic mouse models combined with multi-omics approaches, our recent studies demonstrate that neddylation is essential for embryonic cardiac development, cardiomyocyte maturation, adult cardiac homeostasis, and vascular integrity. Disruption of this pathway leads to profound defects in cardiac structure and function. These findings highlight neddylation as a central regulatory mechanism in cardiovascular biology and suggest that targeting this pathway may offer novel therapeutic opportunities for cardiomyopathy and vascular disease.
About the Series
The Department of Pharmacology invites distinguished researchers to present their work on topics broadly related to pharmacology. Topics range from those closely aligned with the research interests of the department to areas of interest to researchers across the UC Davis campus and the UC Davis School of Medicine.