Microbiology & Molecular Genetics

Knotty Problems: Mariel Vazquez Shares How E. Coli Reconnects Tangled DNA 

If you’ve ever tried to untangle a pair of earbuds, you’ll understand how loops and cords can get twisted up. DNA can get tangled in the same way, and in some cases, has to be cut and reconnected to resolve the knots. Now a team of mathematicians, biologists and computer scientists has unraveled how E. coli bacteria can unlink tangled DNA by a local reconnection process. The math behind the research, recently published in Scientific Reports, could have implications far beyond biology.

“Smart” Immune Cells: Emerging Cancer Therapy Research at UC Davis Receives a Boost with NIH Award

Assistant Professor Sean Collins, Department of Microbiology and Molecular Genetics, has received a $1.5 million award from the National Institutes of Health to advance the development of “smart” immune cells for therapies to treat cancer and other diseases. The five-year NIH Director’s New Innovator Award aims to provide new insight into how to engineer immune cells to control their recruitment and response to tumors.