Extramurally Funded Research

Plant Cell Structure Could Hold Key to Cancer Therapies and Improved Crops

Can the bend of a banana give us insight into cancer? What does the shape of a rice grain have to do with infertility? The proteins that give plants their shape and structure are also involved in human disease. A team led by researchers at the University of California, Davis, has mapped out the structure of a key player, augmin, in exhaustive detail.

Mirror Image Pheromones Help Beetles Swipe Right

There are many ways to communicate with prospective romantic partners: If you are a Japanese scarab beetle, it’s a matter of distinguishing left from right. New work from U.S. and Chinese scientists, published this week in Proceedings of the National Academy of Sciences, shows how these beetles use mirror-image pheromones to find a mate. The work could lead to better monitoring and control of significant agricultural pests.

Plants Balance Adaptability in Skin Cells with Stability in Sex Cells

Mutations drive evolution, but they can also be risky. New research led by plant biologists at the University of California, Davis, published Nov. 10 in Proceedings of the National Academy of Sciences, reveals how plants control mutation rates in different stem cells to balance adaptability with safety and stability. The findings have implications for breeding some of the world’s most important fruit and vegetable crops, such as potatoes and bananas.

Tiny Engines Provide Energy for Life, Mapping Them Could Help Us Treat Genetic Disorders

Inside our cells are tiny engines that supply the energy to sustain life. These protein machines essentially burn our food – producing CO2 and harnessing the energy that is released to sustain growth, movement and even thought.

Each year, roughly 1.6 million people worldwide are born with genetic diseases that disrupt these tiny cellular engines – making life difficult.

“Mutations in these protein complexes are really devastating, and often lethal,” says James Letts, an associate professor of molecular and cellular biology. 

Newly Recognized Pathway Could Protect People with Diabetes from Hypoglycemia

A new study by the University of California, Davis, shows how cells work together to avoid a sudden drop in blood sugar. Understanding these feedback loops could improve the lives of people with diabetes and help them avoid dangerous hypoglycemia.

The work was published Sept. 16 in Proceedings of the National Academy of Sciences

Landmark Discovery Reveals How Chromosomes Are Passed From One Generation to the Next

When a woman becomes pregnant, the outcome of that pregnancy depends on many things — including a crucial event that happened while she was still growing inside her own mother’s womb. It depends on the quality of the egg cells that were already forming inside her fetal ovaries. The DNA-containing chromosomes in those cells must be cut, spliced and sorted perfectly. In males, the same process produces sperm in the testes but occurs only after puberty.